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Read what Public Citizen has to say about the biggest blunders and outrageous offenses in the world of public health, published monthly in Health Letter.

 

Dangers of Overdiagnosis and Overtreatment

March 2012

Sidney M. Wolfe, M.D.

The cover story this month presents clear evidence againstinappropriately-frequent screening for osteoporosis. The more often these testsare done, the more likely it is that many women who do not really haveosteoporosis will be herded into using drugs to prevent fractures. The drugswill not help most of them and also have adverse effects.

One of the most important books concerning the dangers ofundergoing too many tests for a variety of diseases and conditions is Overdiagnosed:Making People Sick in the Pursuit of Health, by Dr. H. Gilbert Welch, aninternist and professor of medicine at Dartmouth College. Welch discusses thedownside of drug treatment for women who really do not have osteoporosis.

In the book, he reviews a study attempting, with drugs, toincrease the bone density of women who have, at the start, near-normal bonedensity (osteopenia) and who have never had a fracture. The results are bestsummed up in the example of 100 patients diagnosed with near-normal bonedensity and treated with osteoporosis-prevention drugs for a lifetime.

  • Winners (treatment saved them from a fracture): 5
  • Treated for Naught (had fractures despite treatment): 44
  • Losers (overdiagnosed: treatment couldn’t help them because they never were going to have fractures): 51

These results show that for every 100 such women, there areonly five winners (saved from a fracture) but 95 women who had fracturesdespite treatment or could not have been helped by treatment because they werenot going to have fractures.

Aside from the poor odds, for most such women, of benefitingfrom drug treatment, there are other downsides. As Dr. Welch points out,referring to bisphosphonates such as alendronate (Fosamax), which increase bonedensity, “There is some concern about the long-term effects of these drugs;they may actually make bones more brittle by changing the bone architecture.They can also disturb calcium metabolism, lead to ulcers in the esophagus and,very rarely, cause bone to die.”

This is but one of many examples of dangerous overdiagnosisreviewed in this book. Heeding Welch’s clearly written advice will surely helpwomen with near-normal bone density, and others at risk of being overdiagnosedand overtreated for other conditions, avoid the unnecessary tests, drugs,surgeries and anxiety that are the inevitable outcome of our overdiagnosisepidemic.